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Year:
1997
| Volume: 5
| Issue: 2
| Pages: 83-87
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Review Article |
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HUMAN VIRUSES ASSOCIATED WITH MALIGNANT DISEASES
Svetlana POPOVIC-PETROVIC, Stevan POPOVIC |
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DOI:
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Abstract: |
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In this paper, literature data of seroepidemiological and molecular-biological studies are shown, by which the hypothesis on the role of virus cancerogenesis in humans is confirmed. In RNA viruses the only association with Human T cell lymphotropic virus type I and resulting adult T cell lymphoma/leukemia and Human T cell lymphotropic virus type II and hairy cells leukemia was confirmed. Oncogenic potential has been proved for a few DNA viruses. The relation between Hepatitis B virus and hepatocellular carcinoma has been known for a long time and possibilities of prevention, have opened new ways in oncology. Epstein-Barr virus is the first discovered human virus with the clear association with Bürrkitt´s lymphoma. It is mentioned as an etiological factor in undifferentiated nasopharyngeal carcinoma, Hodgkin´s disease and some other malignant lymphomas. Human Papillomaviruses draw big attention today, as they are assoctiated with cervical carcinoma and their role in the development of malignant neoplasms of squamous epithelial cells of different anatomical sites is mentioned. For other viruses: Hepatitis C virus, Human Herpesvirus type 6 and 8, adenoviruses, BK and JC there are not enough convincing evidences for the role in human cancerogenesis. |
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Key words:
Retroviruses; Epstein-Barr virus; Hepatitis B virus; Human Papilloma viruses; Virus-associated malignant diseases |
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